With increasing appreciation for the extent and importance of intratumor heterogeneity, much attention in cancer research has focused on profiling heterogeneity on a single patient level.Although true single-cell genomic technologies are rapidly improving, they remain too noisy and costly at present for population-level studies.Bulk sequencing rema
There are many risks and uncertainties in plant construction projects, here because of their complexity, difficulty in loss prediction and size of construction being large.The risk management of plant construction projects should not be relied solely on experiences and intuition of the contractors or the construction managers as it has been in the
Since the emerging of the "novel coronavirus" SARS-CoV-2 and the corresponding respiratory disease COVID-19, the virus has spread all over the world.Being one of the most affected countries in Europe, in March 2020, Germany established several nonpharmaceutical interventions to contain the virus spread, including the closure of schools and child da
Abstract Background Chromosome location is often used as a scaffold to organize genomic information in both the living cell and molecular biological research.Thus, ever-increasing amounts of data about genomic features are stored in public databases and can be readily visualized by genome browsers.To perform in silico experimentation conveniently w